It is directed by Hiroaki Miyamoto (One Piece Film: Gold) and written by Isao Murayama.

[3] The Starry Sky World (星空界, Hoshizora-kai) is the home of the twelve Star Princesses, who are based on the Zodiac signs and maintain order in the universe.

Seeking to revive the princesses and prevent the universe from being consumed in darkness, the aliens Lala and Prunce travel with the fairy Fuwa to Mihoshi Town (観星町, Mihoshi-chō) on Earth, where they meet the imaginative Hikaru Hoshina.

[4] The titular characters are a team of magical girls who use Lala's rocket ship to travel through space.

Ophiuchus was originally the 13th princess, but betrayed them after disagreeing with their plan to bestow half of their collective power to all life in the form of imagination.

In addition, a PreCure Horoscope (プリキュア星座占い) by Arisu Yamada is shown at the end of every episode which features three lucky zodiac signs while in the final episode, Cure Star and Cure Grace tells the viewers that everyone is lucky.

[25][26] An anime film titled Star☆Twinkle Precure the Movie: These Feelings Within The Song of Stars (映画スター☆トゥインクルプリキュア 星の歌に想いをこめて, Eiga Sutā Touinkuru Purikyua Hoshi no Uta ni Omoi wo Komete) was released on October 19, 2019.

A manga adaptation illustrated by Futago Kamikita began serialization in Kodansha's Nakayoshi shoujo magazine from February 1, 2019.