State Road 526 (SR 526) is a 3.306-mile-long (5.320 km) east–west route in the Orlando, Orange County.

After the western terminus of SR 526, State Road 50, it becomes W Washington St.

At the overpass of Interstate 4, State Road 526 runs north–south for 1 block.

It then heads into Downtown Orlando via Robinson Street and follows the northern shore of Lake Eola.

The entire route is in Orlando, Orange County.