From here, it heads east as a two-lane road along 111th Avenue for a mile (1.6 km) before coming to an intersection with US Highway 41 (US 41, Tamiami Trail).

In Hendry County, CR 846 continues east nine miles (14 km) before turning north and terminating near Dinner Island Ranch Wildlife Management Area, which is located about 20 miles (32 km) southwest of Clewiston.

The first segment of what would become CR 846 was built in the late 1940s, extending from Immokalee east to the Hendry County line, and was later added to the state highway system as SR 846.

[6] SR 846 would also provide access to Corkscrew Swamp Sanctuary, which opened its first boardwalk in 1956.

[5] A nine-mile (14 km) segment of SR 846 from Immokalee west was rebuilt with wider lanes in 1977.

[11] SR 846 became CR 846 in the mid-1980s, when the full route was relinquished to county control.