Known as Electric Road, the state highway runs 10.54 miles (16.96 km) from U.S. Route 220 and US 220 Business in Roanoke north to SR 311 at Hanging Rock.

SR 419 begins at a partial cloverleaf interchange with US 220 and US 220 Business near the southern end of the independent city of Roanoke.

US 220 heads north as the Roy Webber Expressway toward Downtown Roanoke and south as Franklin Road toward Rocky Mount and Martinsville.

The four-lane divided highway heads west past the Tanglewood Mall and crosses over Norfolk Southern Railway's Winston-Salem District.

The state highway reduces to a two-lane undivided road and curves west to its terminus at SR 311 at Hanging Rock.