While in MotoGP, Bradl is best known for his performance at Laguna Seca getting the pole position and finishing second in the race behind Marc Marquez, ahead of Valentino Rossi.

He is contracted as a test rider for Honda Racing Corporation in MotoGP and makes occasional wild card appearances and acts as an injury replacement.

Bradl was offered by Alberto Puig to ride his Repsol Honda factory 250cc team for 2007; he withdrew after a couple of tests, but did not stop racing.

Later, he joined the 125cc Spanish Championship with Blusens Aprilia, winning the title just five points ahead of his teammate Scott Redding.

Additionally, from the 2007 Portuguese GP onwards Blusens Aprilia Team principal Raúl Romero placed him on a second bike with veteran Pablo Nieto, replacing Dutchman Hugo van den Berg.

2011 saw Bradl win four of the first six races, and maintained a healthy lead in the championship until Marc Márquez found significant speed halfway through the season.

Márquez, however, suffered a heavy fall during free practice for the Malaysian Grand Prix, and was unable to race for the remainder of the season, due to eyesight problems.

The highlight of his season was a pole-position at the United States Grand Prix, at Laguna Seca,[4] where he also finished second, achieving his first MotoGP podium.

A crash towards the end of the season at the Malaysian Grand Prix – in which he broke an ankle[5] – took him out of contention in the battle for fifth place with Bautista and Crutchlow.

[12][13] For 2022, in the third race of the season at Argentina on 3 April, Bradl finished in position 19 when deputising for Marc Márquez, who was injured in March a few hours before the Indonesian Grand Prix at Mandalika.

(key) (Races in bold indicate pole position; races in italics indicate fastest lap) 1949  B. Ruffo 1950  D. Ambrosini 1951  B. Ruffo 1952  E. Lorenzetti 1953  W. Haas 1954  W. Haas 1955  H. Müller 1956  C. Ubbiali 1957  C. Sandford 1958  T. Provini 1959  C. Ubbiali 1960  C. Ubbiali 1961  M. Hailwood 1962  J. Redman 1963  J. Redman 1964  P. Read 1965  P. Read 1966  M. Hailwood 1967  M. Hailwood 1968  P. Read 1969  K. Carruthers 1970  R. Gould 1971  P. Read 1972  J. Saarinen 1973  D. Braun 1974  W. Villa 1975  W. Villa 1976  W. Villa 1977  M. Lega 1978  K. Ballington 1979  K. Ballington 1980  A. Mang 1981  A. Mang 1982  J. Tournadre 1983  C. Lavado 1984  C. Sarron 1985  F. Spencer 1986  C. Lavado 1987  A. Mang 1988  S. Pons 1989  S. Pons 1990  J. Kocinski 1991  L. Cadalora 1992  L. Cadalora 1993  T. Harada 1994  M. Biaggi 1995  M. Biaggi 1996  M. Biaggi 1997  M. Biaggi 1998  L. Capirossi 1999  V. Rossi 2000  O. Jacque 2001  D. Kato 2002  M. Melandri 2003  M. Poggiali 2004  D. Pedrosa 2005  D. Pedrosa 2006  J. Lorenzo 2007  J. Lorenzo 2008  M. Simoncelli 2009  H. Aoyama 2010  T. Elías 2011  S. Bradl 2012  M. Márquez 2013  P. Espargaró 2014  T. Rabat 2015  J. Zarco 2016  J. Zarco 2017  F. Morbidelli 2018  F. Bagnaia 2019  Á. Márquez 2020  E. Bastianini 2021  R. Gardner 2022  A. Fernández 2023  P. Acosta 2024  A. Ogura