Born in Perugia; he trained there with Giulio Cesare Angeli, and developed a studio in Rome.
Lupattelli claims he studied perspective under the mathematician Lemme Rossi.
He painted the main altarpiece (1632) for the church of San Severo, depicting the Virgin in Glory with the Jesus child, and Saints Benedict, Romuald, Severo, Andrea, Agata, and Lucia.
For the Public library, he painted a Shield of the City with the Virgin and Child and St Catherine.
He is attributed a canvas copy of Raphael's God the Father and Seraphim.