Comini debuted in karting in 2002, racing mostly in Italian and Swiss championships, taking titles in the Bridgestone Cup Switzerland ICA in 2004 and 2005 respectively.

[1][2] Comini began his single-seaters stage of his career in 2006, racing in the Formula Monza 1.2 with Fadini Corse.

[3][4] In 2008, Comini moved to the Italian Formula Renault Championship, racing for Team Dueppì and CO2 Motorsport.

[9] After three races in 2009 in VLN Endurance, Comini made his debut in Eurocup Mégane Trophy for Oregon Team.

He bookended the season with wins at Nürburgring and Barcelona, also he won a reverse-grid race at Silverstone, tying-up with Julien Briché with 58 points.