Perpiniadis was born in Tinos, the youngest of eleven children, of whom only three survived.
He and his family left for Greece as part of the Asia Minor Catastrophe in 1922.
In 1923 he moved to Piraeus, where he came into contact with rebetiko musicians from Asia Minor.
He worked together with other well-known rebetiko musicians such as Vassilis Tsitsanis, and recorded duets with well-known singers such as Rosa Eskenazi, Marika Ninou, Ioanna Georgakopoulou, and Dimitris Perdikopoulos.
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