She was known internationally for her singing and playing of the mbira dzavadzimu, a traditional instrument of the Shona people of Zimbabwe.

[8] Chiweshe performed numerous times in Germany and also participated in the WOMAD festival (1994 in the United States, 1995 in Australia, and 2006 in Spain).

[17][18] Her daughter is the mbira player Virginia Mukwesha [fi], whom Chiweshe trained from a young age.

[20] Chiweshe is considered a ground-breaking Zimbabwean musician, not just for her skills, but for the path for women mbira-players that she forged.

[23] Her work was sampled by many artists, including The New Vets, a Zimbabwean activist rap group, who campaigned for land reform using a track Chiweshe sang on.