[4] In 1880, Panaretoff conducted another unofficial diplomatic mission to London to gain support for Bulgarian acquisition of Eastern Rumelia.

He became the first Special Envoy and Minister Plenipotentiary of Bulgaria to the U.S. after presenting his Letter of Credence to President Woodrow Wilson on December 22, 1914.

[6] He played a critical role in maintaining Bulgarian relations with the Wilson administration through the War, despite a myriad of calls for the breaking of diplomatic ties with the Central Power ally.

In 1918, Panaretov was the only official diplomatic representative of a member country of the Central Powers who continued his work in the capital of the United States.

[7][8] In 1921, Panaretoff served as the ad hoc Bulgarian representative to the League of Nations after the international organization admitted Bulgaria as a member state.