During her time at NYU, she studied animation under Richard Protovin and John Canemaker, and received an award for her student film.

By 1999, McMillan began self-syndicating her cartoons, as well as providing exclusive comic features and illustrations for hundreds of publications worldwide.

Her work has appeared in many publications, including the Los Angeles Times, Daily Beast,[2] South Florida Sun-Sentinel,[3] Yes!

Magazine,[4] Comic Relief, Amarillo Globe-News, Funny Times, Yahoo.com, and the San Francisco Bay Guardian.

[10] From 2009 to 2011, McMillan also drew Code Green, a weekly editorial cartoon that focused "exclusively on the environmental emergency.