[1] He was the son of Richard Lobb of Liskeard, Mill Park, Warleggan, and Tremethick, St Neot, Cornwall, who was briefly MP for Mitchell.
[3][4] After James II had issued his declaration for liberty of conscience (4 April 1687), Lobb was one of the ministers selected by the independents to present an address of thanks to him.
He became somewhat isolated because of his stance towards James;[2] his frequent attendance at court, for which he was sometimes called the 'Jacobite Independent', led the church party to accuse him of promoting a repeal of the Test Act.
[5] After serving as a "preacher to a congregation of dissenting protestants at his house in Hampstead",[6] the precursor to what later became Rosslyn Hill Unitarian Chapel, in 1694 he was chosen to fill one of the vacancies, occasioned by the exclusion of Daniel Williams, among the lecturers at Pinners' Hall, Old Broad Street.
[4] In conjunction with John Humfrey, Lobb wrote in 1680 an Answer ... by some Nonconformists to a sermon preached by Edward Stillingfleet on the ”mischief of separation”.
At length Lobb sent forth An Appeal to Dr. Stillingfleet and Dr. Edwards concerning Christ's Satisfaction (1698), in which he insinuated that Williams and Richard Baxter favoured Socinianism.