Lowe's plays have dealt with subjects ranging from the takeover of Tibet by the Chinese People's Liberation Army in 1959 (Tibetan Inroads) to a dying DH Lawrence trying find a publisher for Lady Chatterley (Empty Bed Blues); from Donald McGill postcards (Cards and Kisses on the Bottom) to Dr John Dee (The Alchemical Wedding).
His theatre and television work has featured actors such as Bruce Alexander, Warren Clarke, George Costigan, Kenneth Cranham, Sharon Duce, Emma Fielding, Brian Glover, Nigel Hawthorne, Bill Paterson, Neil Pearson, Kathryn Pogson, Linus Roache, Colin Tarrant, Marjorie Yates, Harriet Walter and Rachel Weisz.
After university, Lowe worked in various jobs while writing, including part-time lecturer, clerk, hospital receptionist, newspaper distributor, advertising manager, housepainter, barman and civil servant.
While working as a part-time shepherd in the Yorkshire Dales, he was commissioned by Alan Ayckbourn to write a comedy double-bill, Comic Pictures, and joined his Scarborough Theatre in the Round company as an actor and writer.
It was published in 1985 during a period of increased tension towards the end of the Cold War, and Lowe's introduction quoted from Gabriel Garcia Marquez's Nobel acceptance speech, "we, the inventors of tales, who will believe anything, feel entitled to believe that it is not yet too late to engage in the creation of a utopia of a very different kind.