A native of Polkton, North Carolina, Anthony attended Anson High School, where he was a four-year starter.

In a Week 3 game against the Carolina Panthers, Anthony was fined $17,363 for his hit on wide receiver Devin Funchess.

In the same game, Anthony also became the first person in NFL history to return a blocked kick for two points after Kevin Williams blocked an extra point, following a rule change that took effect in the offseason to allow such returns.

[9] Anthony recorded his 100th tackle in a Week 15 game against the Detroit Lions, where he also forced a fumble.

He became the first Saints' rookie to record 100 tackles in a season since Hall of Fame linebacker Rickey Jackson.

Anthony finished his rookie season with 112 tackles, one sack, one interception, and two forced fumbles.

[13] On May 2, 2018, the Dolphins declined the fifth-year option on Anthony's contract, making him a free agent in 2019.

[21] In 2022, Anthony began his coaching career, joining the staff at his alma mater, Clemson, as a defensive graduate assistant.