[2] It follows Wilkes Avenue and the Sterling Lyon Parkway, running east from an interchange at the Perimeter Highway (PTH 100) to Waverley Street (Route 80).

Heading west from Winnipeg, it continues as Provincial Road 427 into the Rural Municipality of Headingley.

Wilkes Avenue runs parallel to the main Canadian National Railway line.

[2] Route 145 previously followed Wilkes Avenue in its entirety; however, a segment of Wilkes near Kenaston Boulevard (Route 90) was demolished as part of the Kenaston Underpass project in 2005.

He was a strong advocate for residential development south of Portage Avenue (Route 85).