Following the success of Once, Kazee acted on multiple television series, most notably playing Gus Pfender in the fifth season of Shameless.

Kazee returned to theater in 2018, starring as Edward in the Chicago tryout of Pretty Woman: The Musical.

[2] Kazee moved to New York City in 2002 and received his MFA from the Graduate Acting Program at NYU's Tisch School of the Arts in 2005.

[6] In 2007, he starred as Bill Starbuck in the revival of 110 in the Shade on Broadway,[7] In 2008, he played Sobinsky in To Be Or Not To Be, which ran from September 16 through November 16 at the Samuel J. Friedman Theatre.

[8] Kazee starred as Guy in the stage adaptation of Once,[9] He originated the role off-Broadway when it opened at the New York Theatre Workshop on December 6, 2011.

[13] In 2017 it was announced that Kazee would star in the stage adaptation of the 1990 film Pretty Woman, opposite Samantha Barks in her Broadway debut.

[14][15] After performing as Edward in the Chicago production, Kazee left Pretty Woman: The Musical due to "family reasons.