[2][3] When Keene was a volunteer DJ at the college radio station WTJU in Charlottesville, Virginia in the 1990s,[4] he became friends with musician David Berman and future members of the band Pavement, and seeing them hustle to sell CDs and merchandise shaped his approach to producing and selling art.

"[5] In addition to selling pieces by quantity on his website,[8] he has created album art, video sets, stage sets, and posters for bands including Silver Jews, Pavement, The Apples in Stereo, Soul Coughing, The Klezmatics, and Dave Matthews Band.

In November 1997 he "worked in the window of the Goldie Paley Gallery at the Moore College of Art and Design in Philadelphia.

[11] His work has also been exhibited internationally in England, Germany, and Australia, and has been on display in two of David Chang's restaurants.

In 2022, to assist with launching the book, Keene participated in 30-year retrospectives in both Los Angeles, Calif., and Brooklyn, N.Y. Curated and produced by Efram, these events featured over one hundred pieces at each event (many of which ended up in book as well as pieces from local collections), experiential painting in situ by Keene, and music performances in the spaces.