Mizerak is considered one of the best straight pool players of all time, dominant in the game during the 1970s, winning over 70 tournaments during his career.

Mizerak, a lefty, began playing pool under the guidance of his father, who for many years had been the New Jersey State Champion.

[2] After some time at Saint Ambrose University in Davenport, Iowa, Mizerak graduated from Athens College with a degree in education, history, and psychology in 1967.

He then took a position as a history and geography teacher at a secondary school in Perth Amboy, New Jersey where he taught for 13 years.

Mizerak became famous outside of pool circles after appearing in a humorous commercial for Miller Lite beer in 1978, in which he executed three complicated shots (which took more than 100 "takes"), then proclaimed that you can "really work up a thirst, even when you're just showing off."

Due to his fame as a result of this commercial, in 1980 Mizerak quit his job as a teacher to further promote Miller Lite in billiards demonstrations at trade shows while continuing on the tournament circuit.

Mizerak by this time had established himself as one of the best players in the world winning the BCA U.S. Open Straight Pool Championship four years in a row, a record which still stands.

In 1979 Mizerak once again proved his dominance by winning the U.S. Open 9-ball Championship, defeating Jim Rempe in the finals and going undefeated in the tournament.

Mizerak won back-to-back World Straight Pool Championship titles in 1982 and 1983, and multiple nine-ball tournaments throughout the 1980s.

He competed in the 1978 Canadian Open, Mizerak won his first match, including an 81 break, but lost to Tony Knowles by 9 frames to 7.

[5][6] Mizerak owned and operated pool halls in the West Palm Beach-Lake Park, Florida area during the 1990s and 2000s.