She attended the Bronx High School of Science before dropping out, earning money as a teenager by nannying and waitressing.

[2] She began her career playing in the local and regional scenes of New York City, including the Howard Beach Billiard Club in Queens, owned by music producer Gabe Vigorito, who first compared her demeanor to a black widow spider and financed her early tournament expenses.

1 female pool player in the world during the 1990s, and received the Women's Professional Billiard Association (WPBA) Sportsperson of the Year Award in 1998.

[10][11][12] Lee has three additional adult children, two of whom are her step-daughters from her marriage to George Breedlove, a professional pool player nicknamed "the Flamethrower".

[1][14] In May 2022, it was reported that her chemotherapy treatments were "successful" [15] A documentary about her life directed by Ursula Liang, Jeanette Lee Vs., premiered at the Doc NYC film festival on November 12, 2022.