He was the Republican nominee for the United States Congress in New Hampshire's 2nd congressional district in 2018 and 2020, losing both times to Democratic incumbent Annie Kuster.

[2] After retiring from the military, Negron worked for defense contractors Lockheed Martin and General Dynamics before founding his own contracting firm Integron LLC in 2005.

The one successful piece of legislation sponsored by Negron involved removing the limitation on a charter schools incurring long term debt.

[8]*^a Midway into his first term in the state legislature, Negron announced a 2018 run as a Republican candidate for Congress in New Hampshire's 2nd congressional district.

[13] In 2020, Negron gained the Republican nomination and in a rematch ran against Democratic representative Ann McLane Kuster.