[10] In 1982 he moved from Los Angeles to Chicago,[11] and from then until 1985 he managed BehaviorScan test markets for Information Resources, Inc.[12] In 1996, he was diagnosed with non-Hodgkin lymphoma, and in February 1997, he was treated with Rituxan.

[21][22] In 2008, Sailer published his first book, America's Half-Blood Prince, an analysis of Barack Obama based on his memoir Dreams from My Father.

[7] In his writing for VDARE, Sailer has described black people as tending "to possess poorer native judgment than members of better educated groups" and thus need stricter moral guidance from society.

"[30] The article on Hurricane Katrina was criticized for being racist by Media Matters for America and the Southern Poverty Law Center, as well as some conservative commentators.

[31][19] Neoconservative[32] columnist John Podhoretz wrote in the National Review Online blog that Sailer's statement was "shockingly racist and paternalistic" as well as "disgusting".

[30] Rodolfo Acuña, a Chicano studies professor, regards Sailer's statements on race as providing "a pretext and a negative justification for discriminating against US Latinos in the context of US history".

In order to do this, Sailer suggested that Republicans support economic protectionism, identity politics, and express opposition to immigration, among other issues.