He is best known for portraying Bobby Bacala on The Sopranos, Leo Boykewich on The Secret Life of the American Teenager, and Detective Anthony Abetemarco on Blue Bloods.

[12] His many television appearances include Angel, Casino Cinema, Columbo, Star Trek: Enterprise, Hollywood Squares, Joey, Law & Order, Law & Order: Special Victims Unit, My Wife and Kids, Ed, Jeopardy!, George Lopez, Tim and Eric Awesome Show, Great Job!

[15] He also made an uncredited appearance along with fellow Soprano star Vincent Pastore on a sixth season episode of Aqua Teen Hunger Force entitled "She Creature".

In February 2007, he began to make appearances for Total Nonstop Action Wrestling, on Spike TV, siding with Team 3D as their cousin in their ongoing battle against The Latin American Xchange.

From 2008 to 2012, Schirripa had a recurring role in the ABC Family show, The Secret Life of the American Teenager, as Leo Boykewich, Ben's dad.

In 2009, he made a cameo appearance alongside fellow Sopranos actor Frank Vincent in Stargate Atlantis episode "Vegas".

In the fall of 2010, Schirripa had a guest star role in the digital comedy short film, Lil DPC, from writer/director Michael Ratner, which also features rapper Fat Joe and Blink 182's Mark Hoppus.

entitled "Stan Goes on the Pill", and played Vito in the silver screen adaptation Jersey Boys, directed by Clint Eastwood.

Anthony Abetemarco, an investigator who works with assistant district attorney Erin Reagan on the CBS series Blue Bloods.

Nicky Deuce also featured supporting roles filled by James Gandolfini, Michael Imperioli, Tony Sirico, and Vincent Curatola of The Sopranos fame.

On April 3, 2014, Schirripa gave a theatrical performance in a special production of Guys and Dolls alongside Nathan Lane, Patrick Wilson, and Megan Mullally at Carnegie Hall.

[22] In 2014, Schirripa launched a line of organic vegan pasta sauces under the business name of Uncle Steve's Italian Specialties Group.