(2012), Hot in Cleveland (2012), Clipped (2015), The Big Bang Theory (2018–2019), and Good Girls (2020–2021) and in the films Jurassic World (2015),[1] The Unicorn (2018), and The Wrong Missy (2020).

[9] At an early age she filmed sketches with her older brother and later at Evanston Township High School[10] she participated in the annual student revue and variety show YAMO.

[1] After almost a year in Los Angeles, Lapkus began landing roles in a number of commercials, including Snickers and Jack in the Box[10] as well as a sketch on Jimmy Kimmel Live!

[10] After self-taping her audition, Lapkus was cast as correctional officer Susan Fischer on the first and second seasons of the Netflix series Orange is the New Black.

[12] In 2015, Lapkus and the cast won the Screen Actors Guild Award for Outstanding Performance by an Ensemble in a Comedy Series.

Her guests have included Paul F. Tompkins, Betsy Sodaro, Andy Daly, Nick Kroll, and Scott Aukerman.

On the podcast, Lapkus and Byer have covered the Star Wars, The Lord of the Rings, Tyler Perry, Fast & Furious, Marvel Cinematic Universe, and Batman franchises.