[9] Salzberg did his undergraduate studies at Yale University where he received his Bachelor of Arts degree in English in 1980.

In 2014, he was named a Bloomberg Distinguished Professor at Johns Hopkins University for his accomplishments as an interdisciplinary researcher and excellence in teaching the next generation of scholars.

[19] These findings helped the FBI track the source of the attacks to a single vial at Ft. Detrick in Frederick, Maryland.

These include the "Tuxedo" suite, comprising the Bowtie, TopHat, and Cufflinks programs, which have been cited tens of thousands of times in the years since their publication.

Salzberg has also been a vocal advocate against pseudoscience and has authored editorials and appeared in print media on this topic.

Since 2010, he has written a column at Forbes magazine[22] on science, medicine, and pseudoscience, where he has published hundreds of articles that have received tens of millions of views.

[23] Salzberg was a charter member of the Cambridge Working Group in 2014, which was created to express alarm in the scientific community over the creation of highly transmissible and contagious viruses (also called Gain-of-function research) and the likelihood of an accidental lab release.