It lies mostly in the northern tip of the České Budějovice Basin, but the municipal territory also extends to the Blatná Uplands on the north and to the Bohemian Forest Foothills on the south.

The highest point is the hill Velká Kakada at 564 m (1,850 ft) above sea level.

Strakonice has a cool, wet, and temperate inland version of a humid continental climate (Dfb).

[6] In 1420 the Hussite commander Jan Žižka occupied Strakonice, but failed to capture the fortress.

Strakonice Castle experienced an extensive reconstruction to a representation residence of the Grand Priors of the Order in the 16th century, the later modifications were minor only.

In the 1860s, the town was connected with České Budějovice and Plzeň by railway, which helped its further development.

[9] The tradition of beer brewing in the town started in 1367 and the Burghers' Brewery was founded in 1649.

Its exhibitions focus on motorcycles, weapons, bagpipers and the traditional fez production.

[15] The Church of Saint Margaret was built in the late Gothic style with many Renaissance elements in 1580–1583.