Directed by Fred Wolf, who also co-wrote the film with Peter Gaulke, the film stars Steve Zahn, Allen Covert, Jonah Hill, Kevin Heffernan, Ashley Scott, Peter Dante, Harry Hamlin, Robert Patrick, Joe Don Baker, Justin Long, Jeff Garlin, and Ernest Borgnine.

Peter and Fred are told by network head Ed Lawson about the negative aspects of Strange Wilderness since the death of Peter's father like low ratings, poor content, inappropriate footage, referring to all indigenous peoples as pygmies aside from the littering, and bad things happening to people in footage like an alligator attack on someone and a guy at a peace rally who was on fire.

Peter brainstorms ideas to keep Strange Wilderness on the air with Fred, equipment manager Lynn Cooker, driver Danny Gutierrez, camera man Junior, and his father's old friend/original cameraman Milas.

Bill Calhoun, his dad's friend, brings him photos of Bigfoot hiding in Ecuador and a map to his cave.

They also bring in two more people: Whitaker, a former car mechanic now animal handler; and Cheryl, a travel agent.

Stopping to shoot footage of sea lions, Danny dresses up as a seal for better angles, gets attacked by a shark, and ends up hospitalized.

While urinating in the bushes, Peter is attacked by a mother turkey, ending up with his penis inside its mouth.

During the night, Cheryl catches up with them and explains she saw Gus stealing their equipment and pretended to run off with him so she could get the map back.

It grossed $3 million over its first weekend, placing in the 13th spot in the North American box office.

The website's critical consensus reads, "Strange Wilderness is a laugh-free comedy that's both aimless and overly crass."

[4] In his review for The New York Times, Matt Zoller Seitz wrote, "What rankles isn’t the gross-out humor or the verbal non sequiturs, which are expected, even welcome, in this sort of movie.