The reservoir became obsolete in the early 20th century by construction of the East Bay Municipal Utility District water system.

In the latter half of the 19th century, a road bridge and a railroad trestle both spanned Strawberry Creek in the downtown section at what is now the intersection of Shattuck Avenue and Allston Way.

[3] The creek has been culverted over the years in several other locations, notably in public-works projects during the Great Depression of the 1930s, but has remained open through most of the UC campus, except in the central glade where the two small middle forks were long ago filled in.

[5] Strawberry Creek used to have around 13 native fish species, including coldwater salmonids, anadromous steelhead and coho salmon.

[8] Finally, the introduction of non-native crayfish species Pacifastacus leniusculus and Procambarus clarkii have had a negative impact on the native fish population.

The creek is also open through several private yards in the blocks east of the park, starting just below (west of) Sacramento Street.

This proposal, backed largely by Ecocity Builders' Richard Register, would not restore the creek's original riparian habitat or path (which lies one block south along Allston Way).

[12] At the mouth of Strawberry Creek where it enters San Francisco Bay, the local indigenous people built up a shellmound.

Until the end of the 1700s, the Ohlone indigenous people would eat shellfish provided by the creek and pile the empty shells into a mound, signifying a sacred burial site.

Jacobs' Landing, established early during the California Gold Rush, was the nucleus around which the Ocean View settlement that predated Berkeley was founded.

The creek now enters San Francisco Bay from a rectangular concrete culvert mouth, south of University Avenue and west of the I-80/580 freeway, behind Sea Breeze Market and Deli.

The university's central campus, including parking lots, green spaces, roadways, and Lawrence Berkeley Labs were built in this area.