Sequence alignments of actinomycetotal genomes have led to the identification of three conserved signature indels which are unique to the order Streptomycetales.

The enzyme PBGD contains a four-amino-acid insertion which is present in all Streptomyces species and Kitasatospora setae, but not any other Actinomycetota.

Additionally, 11 conserved signature proteins have been identified which are found in all sequenced Streptomyces species and K. setae.

These proteins are believed to be unique to the Streptomycetales order, thus provide molecular markers which can be used to distinguish this group from the rest of the Actinomycetota.

[4] The currently accepted taxonomy is based on the List of Prokaryotic names with Standing in Nomenclature (LPSN)[3] and National Center for Biotechnology Information (NCBI)[5] Catenulisporaceae Carbonactinospora thermoautotrophica Embleya Phaeacidiphilus Streptacidiphilus Kitasatospora Wenjunlia vitaminophila Streptomyces Catenulisporales Vallicoccaceae Motilibacteraceae Allostreptomyces Streptomyces burgazadensis Saricaoglu et al. 2014 Yinghuangia soli Embleya Yinghuangia Streptomyces [incl.