It was serialized in Kodansha's Weekly Shōnen Magazine from August 2017 to February 2020, with its chapters collected into fourteen tankōbon volumes.

The series follows the daily life of a high-school student Futaro Uesugi, who is hired as a private tutor for a group of identical quintuplets: Ichika, Nino, Miku, Yotsuba, and Itsuki Nakano.

At the very beginning of the story, it is shown that the events are being told in a flashback, while an adult Futaro prepares to marry one of the Nakano Quintuplets whose identity is only revealed near the end of the series.

An anime television series adaptation produced by Tezuka Productions aired from January to March 2019 on TBS and other channels.

The outline for a story about "a group of quintuplets falling in love with the same person" existed even before the serialization of Haruba's previous work, Karma of Purgatory (2014–2015), but was rejected by his editor-in-charge.

A year later, as Karma of Purgatory was finishing, Haruba pitched various ideas to the editor, and the "quintuplets" concept was accepted.

As the characters were quintuplets, Haruba wanted a way to make them memorable to the reader (similar to how colour was used in Super Sentai) with Ichika (yellow), Nino (purple), Miku (blue), Yotsuba (green), and Itsuki (red), and just as the design was almost confirmed he had the idea of adding numbers in their names.

[3] While it is often the norm for harem romantic comedy manga to have sexualized depictions of characters, Haruba has said that he tried to avoid this to some extent after Vol.

Before the serialization, a one-shot manga of the same name had been published in 2017 issue 8 of Kodansha's Weekly Shōnen Magazine on August 9, 2017, and received positive comments.

[2] An anime television series adaptation was announced in the combined 36th and 37th issue of Weekly Shōnen Magazine on August 8, 2018.

[20] Kaori is replacing Satoshi Kuwabara as the director of the season, and Keiichirō Ōchi is returning to write the scripts.

It was originally scheduled to premiere in October 2020,[21] but due to issues caused by the COVID-19 pandemic, the anime aired from January 8 to March 26, 2021.

The special is directed by Yukihiro Miyamoto and animated by Shaft, with Keiichirō Ōchi returning to write the scripts.

The anime is an original project with the story being drafted by Haruba, and recounts Futaro and the quintuplets' honeymoon trip.

[33] For the first season, Kana Hanazawa, Ayana Taketatsu, Miku Itō, Ayane Sakura, and Inori Minase performed the opening theme song "Quintuplet Feelings" (五等分の気持ち, Gotōbun no Kimochi) as the group The Nakano Family's Quintuplets (中野家の五つ子, Nakano-ke no Itsutsugo), while Aya Uchida performed the ending theme song "Sign".

[33] Characters from the series appeared in a collaboration event in the mobile video game Venus 11 Vivid!!

[35] A mobile game based on the series titled The Quintessential Quintuplets: The Quintuplets Can't Divide the Puzzle into Five Equal Parts (Japanese: 五等分の花嫁 五つ子ちゃんはパズルを五等分できない。, Hepburn: Gotoubun no Hanayome: Itsutsu-ko-chan wa Puzzle wo Gotoubun Dekinai.)

[41] A visual novel based on the film, titled The Quintessential Quintuplets Movie: Five Memories of My Time with You (映画 五等分の花嫁　～君と過ごした五つの思い出～, Eiga Gotoubun no Hanayome Kimi to Sugoshita Itsutsu no Omoide) was developed by Mages for the Nintendo Switch and PlayStation 4, and was released on June 2, 2022 in Japan.

[2] Paul Jensen of Anime News Network found the series enjoyable and rated a 4 out of 5 to the series, as he commented, "The jokes are funny, the characters range from tolerable to likable, the fanservice doesn't go overboard, and there's no creepy or obnoxious plot point to spoil the party.

There's nothing revolutionary about it, but it does a lot of basic things well without showing any major flaws, and that's enough to make this premiere good clean (well, clean-ish) fun.

Kyle Rogacion of Goomba Stomp praised the plot of the anime but criticized its art style and fanservice gags.