Ita Buttrose was the first presenter of the show to be named, and her appointment drew much media attention as she was 71 years of age at the time.

It was later announced it would premiere on 4 November 2013 as part of Ten's brand new morning lineup which also included the short-lived breakfast show Wake Up.

[13][14] On 10 March 2014, Studio 10 interviewed Justin Lyons, the cameraman who was with Steve Irwin when he died from a stingray injury in 2006.

A separate edition of the show airs in Perth, with a mix of local content as well as interviews, segments and features from the East Coast version.

[21][22][23] In April 2018, Buttrose resigned as panelist to focus on other parts of her life, including spending more time with her grandchildren and writing.

[27] In August 2018, Drysdale announced she would be taking the rest of the year off the show, due to exhaustion caused by travelling between Sydney and the Gold Coast, where she resides.

[31] In December 2019, it was announced that 10 News First Perth's Narelda Jacobs would be relocating to Sydney and joining Studio 10 as a panelist and reporter on 13 January 2020.

[35][36] In September 2020, it was announced that Dancing with the Stars judge Tristan MacManus would join the show as co-host alongside Harris.

[38] On 23 November 2022, Harris, the last remaining original host, announced that she would be leaving the show after nine years to replace Carrie Bickmore as co-host of The Project.

[40] Following Harris departure, the show was again reformatted from two person format to a hosting trio with Bishop and Jacobs joining MacManus as co-host, and they all presented the news and entertainment.

[50][51] In an effort to build ratings, unlike its rivals, Studio 10 remained on air for the entirety of the summer 2013/14 period.

[52] This strategy worked, and its viewership numbers over the summer period increasing slowly,[53] allowing the show to average a respectable 50,000 viewers by April 2014.

[54] These ratings caused 10 CEO Hamish McLennan to state that the show is "performing well" and subsequently was not axed along with its lead in Wake Up in May 2014.

On occasion, both Bishop and Bennett were unavailable and fill-in presenters included Anna Kooiman, John Caldwell and Richard Reid.

This segment was previously presented in conjunction with The Hoopla but from 2015 articles and guests were sourced from News.com.au and occasionally KidSpot (Melissa Wilson).

Each Monday morning until 2014, Jonathan Coleman joined the panel to take a look at events which happened during that week in history.

It was billed as "Australia's cheapest game show" and involved the hosts, guest panellist and usually a studio audience member competing for the grand prize of AU$5.

Hildebrand later apologised for his remarks after a confrontation by Rosie Batty, whose partner murdered their 11-year-old son and was scheduled to appear on the show later that day.