These rooms contained, either physically or in the form of artistic depictions, books, tomes, scientific instruments, and other symbols of knowledge, particularly if they were associated with Classical Greece or Rome.

[1] Elaborately decorated with paintings and intricate woodwork, studioli became a sign of status and sophistication for the nobility, court officials, and artists of the Italian Renaissance.

In addition for being a capable military leader, Federico was noted for being a prolific patron of the arts; his activities, such as the employing of artists, architects, and writers resulted in him being given the moniker "the Light of Italy".

The artists' use of intarsia (inlaid wood) to render realistic, two-dimensional images of latticework cabinets, drawers, and siding is representative of the rediscovery of linear perspective in mid-15th century Italy.

[2][1] A phrase, done in gold-on-blue frieze along the upper panels of the room, reads; "You see the eternal nurselings of the venerable mother, men pre-eminent in learning and genius, How they fall with bared neck before …knee.