It was founded some time before 1176 in the hamlet of Studley in what is now the village of Horton-cum-Studley, 7 miles (11 km) northeast of Oxford in Oxfordshire, England, at 1 Horton Hill Road.
In 1947 the priory was leased by Raymond and Tessa Bawtree, who (with their partner, Wilma Hessey) ran it as a country-house hotel for the next 14 years.
During that time, many eminent guests stayed there (including Adrian Boult, Gilbert Murray, Beverley Nichols and Sandy Wilson; it was a favourite hostelry of C.S.
The priory was bought by the Parke family, who continued to run it as a hotel until 2004 when the business was placed in receivership due to mounting financial losses.
It was used as a filming location for the exterior of Sir Thomas More's Chelsea home in the 1966 version of Robert Bolt's A Man for All Seasons (interior shots were done in a studio, not at Studley Priory).