The series was launched in 1956 along with another Sheldon Mayer creation The Three Mouseketeers,[1] and it was supervised by Larry Nadle, who edited DC's humor line until his death in 1963.

[6] In 1992, Sugar and Spike #99 was published as part of the DC Silver Age Classics series;[7][8] this featured two previously unpublished stories by Mayer.

DC Comics writer and executive Paul Levitz has described Sugar and Spike as being "Mayer's most charming and enduring creation".

[13] They appear as theme park characters in Justice League Spectacular;[14] as being baby-sat by Cassie Sandsmark in Wonder Woman #113;[15] and as teenagers on the crowded cover of Legionnaires #43.

[19] The comic featured the misadventures of two toddlers named Sugar Plumm and Cecil "Spike" Wilson, who possessed the ability to communicate via "baby talk" with each other and to other infants, but not to adults.