Suicide crisis

More subtle clues include preparing for death for no apparent reason (such as putting affairs in order, changing a will, etc.

[7] Suicide is often committed in response to a cause of depression, such as the cessation of a romantic relationship, serious illness or injury (like the loss of a limb or blindness), the death of a loved one, financial problems or poverty, guilt or fear of getting caught for something the person did, drug abuse, old age, concerns with gender identity, among others.

[9][10] The drug is given by a single intravenous infusion at doses less than those used in anesthesia, and preliminary data have indicated it produces a rapid (within 2 hours) and relatively sustained (about 1–2 weeks long) significant reduction in symptoms in some patients.

[11] Initial studies with ketamine have sparked scientific and clinical interest due to its rapid onset,[12] and because it appears to work by blocking NMDA receptors for glutamate, a different mechanism from most modern antidepressants that operate on other targets.

Supporting those in crisis to make independent decisions,[16][17] and adapting terminology, for example using the phrase ‘sort (x) out’[18] can aid in minimising resistance to the help being offered.