[12] The 2010 United States Census[14] reported that Suisun City had a population of 28,111.

1,443 households (16.2%) were made up of individuals, and 350 (3.9%) had someone living alone who was 65 years of age or older.

14.3% of all households were made up of individuals, and 3.0% had someone living alone who was 65 years of age or older.

Its location made it ideal for commerce and transportation during the California Gold Rush.

By 1879 Central Pacific Railroad owned the Cal-P mainline and rerouted the transcontinental overland route through the new branch from Port Costa, via the railroad ferry Solano to Benicia, across the Suisun Marsh to Suisun City, putting the region directly on the overland route from San Francisco to Ogden and beyond.

[16] In 1888, a fire destroyed much of downtown Suisun, including many city landmarks, such as the Robert Hotel, Crowley's saloon, the Union Hotel, and the Orkel grain warehouses.

Citizens considered abandoning the city after the devastation, but instead decided to rebuild and raise money to construct a waterworks system that would allow them to fight future fires more effectively.

[17] In the 1960s and 1970s, Suisun City experienced rapid growth as the San Francisco Bay Area's suburban ring expanded to the formerly rural Solano County.

Also in the 1960s, Interstate 80 was constructed two miles (3.2 km) outside the city, effectively moving commercial traffic away from railways and water conveyance.