Semiz Mehmed Pasha (1596 – July 1646) was an Ottoman grand vizier and a descendant of Suleiman the Magnificent.
[1] His mother was Ayşe Hanım, daughter of Saliha Hanımsultan, sister of Abdurrahman, and Cığalazade Yusuf Sinan Pasha.
This appointment was probably due to the secret power struggle between him and the grand vizier, Kemankeş Mustafa Pasha.
Kemankeş Mustafa Pasha was a victim of palace intrigues and a hodja quack named Djindji Khodja.
Sultan Ibrahim deposed him in 1645 and sent him to Crete, the theatre of the recently started war, as the commander of the army (Turkish: serdar).