Sultiame

Sultiame was first synthesised in the laboratories of Bayer AG in the mid-1950s and eventually launched as Ospolot in Europe and other markets the early 1960s.

The brand was transferred to Desitin GmbH in 1993 and is sold in several European countries, in Israel, Japan, and Australia.

It was only in 1988, that the German child neurologist Hermann Doose discovered its specific effects in benign focal epilepsies of childhood.

Less common adverse effects include giddiness, rash, Stevens–Johnson syndrome, nausea, weight loss, leukopenia, headache, depression, drooling, increased pain, insomnia, status epilepticus.

Sulfanilamide can be reacted with ω-chlorobutylsulfonyl chloride and aqueous sodium carbonate to form the presumed intermediate (middle), which spontaneously cyclizes to give the drug.

Sultiame synthesis: B. Helferich and R. Behnisch, U.S. patent 2,916,489 (1959).