Set in modern-day South London, the series is about a group of five ordinary black people, unified by family history of sickle cell disease.

The series features an ensemble cast including; Tosin Cole, Adelayo Adedayo, Josh Tedeku, Nadine Mills, Eric Kofi-Abrefa, Calvin Demba, Ghetts, Digga D, and Eddie Marsan.

Supacell received highly positive reviews from critics and audiences for its performances, direction, writing, cinematography, and visual effects, and for raising awareness of sickle cell disease.

[1] Five black people from South London (a delivery driver, a gang leader, a nurse, a financially-struggling father, and a Cockney drug dealer) are unified by a family history of sickle cell disease and unexpectedly develop superpowers.

He began writing the series during the COVID-19 pandemic, following the cancellation of his planned second film American Son, a remake of the 2009 French film A Prophet, starring Russell Crowe and Stephan James, for Paramount Pictures, as a result of the pandemic, and in November 2021, the series was announced in November 2021 with Mouktar Mohammed and Henrietta Lee of New Wave as executive producer and associate producer, respectively.

[6] In August 2022, Tosin Cole was announced in the lead role along with a cast that included Adelayo Adedayo, Nadine Mills, Eric Kofi-Abrefa, Calvin Demba, Josh Tedeku, Rayxia Ojo and Giacomo Mancini.

[18] Aramide Tinubu of Variety praised the series' unique perspective on the genre with its characters and settings, remarking "Supacell considers how individualism has caused fractures in Western societies, specifically in Black communities that previously thrived because of collectivity.