Because the DC Universe was revamped after the events of Crisis on Infinite Earths, the previous continuity before that series (colloquially referred to as "pre-Crisis") was voided.

Reintroductions of classic villains were part of the new Superman series' first year, featuring the first post-Crisis appearances of characters such as Metallo[3] and Mister Mxyzptlk[4] and the introduction of Supergirl.

[5] The historic engagement of Lois Lane and Clark Kent[6][7] was one of the major events in the book's run.

[22] Loeb's run on the series included the crossover event Our Worlds at War,[23] which saw the destruction of Topeka, Kansas,[24] serious damage to Clark Kent's nearby hometown of Smallville, and Superman adopting a costume of more somber colors to mourn the heavy loss of life during the event.

In 2004–2005, artist Jim Lee, who had recently concluded the Batman: Hush storyline with Loeb, provided the artwork for a Superman story by writer Brian Azzarello.

[29] With the publication of issue #226 (April 2006),[30] the series was canceled as part of the company-wide Infinite Crisis event.