Labs expedition uncovers an ancient derelict spacecraft in the jungles of Central America.

Superman investigates the ship and is afflicted by an alien virus causing his powers to fluctuate wildly.

He plans to use the alien technology to facilitate selective global genocide based on genetic sequencing, but is unaware of the arrival of the hunter from the galaxy known as the Predator.

The latter considers Superman as a worthy opponent and begins stalking him while concurrently seeking to reclaim the stolen technology appropriated by the scientist.

The series has been collected as a trade paperback: Since the character of The Predator clashed with Superman, the alien hunter experienced other comic book crossovers.