Supersaxo is the surname of a number of unrelated families of the Upper Valais.
The most notable bearers of the name are the Supersaxo auf der Flüe of Naters.
They are descended from the Manegoldi, a family of episcopal ministeriales originally of Ernen.
After 1352, the castle was occupied by the castellanus of Naters and it intermittently served as residence of the prince-bishops of Sion in the 15th and 16th centuries.
Other (unrelated) families called Supersaxo are found in Jeizinen (Gampel), Saas-Grund (extinct) and Michel-Supersaxo of Brig.