He was born in Oyo State, Nigeria and married Deborah Ayokunle (nee Adesipo).
Olasupo Ayokunle was born into the family of Amos Ogunkunle and Theresa Bibilari Ogunkunle of Jagun Alawusa House, Isheke, Oyo Town in Oyo State.
[1] He attended Oniyanrin Baptist Central Day School, Iware Road, Oyo State, graduated in 1971, earning his West African School Leaving Certificate Ordinary Level in 1977.
[3][4] In 2016 he was made President of the Christian Association of Nigeria (CAN], the largest Christian ecumenical body in Africa, after Pastor Ayo Oritsejafor left office.
In October 2022, a Nigerian national honour of Commander of the Order of the Niger (CON) was conferred on him by President Muhammadu Buhari.