It is the opening track on their sixth studio album, The 2nd Law (2012), and was released as the fourth single on 20 February 2013.

According to frontman Matthew Bellamy, "Supremacy" sees the band going to "absurd levels",[2] while according to the French magazine Jeuxactu the song has elements of "Kashmir" from Led Zeppelin in its guitar riff and orchestration.

[5] The song was first announced as the next single after "Follow Me", with a released date programmed for February 25, 2013.

[6] It features people with black metal corpse paint doing extreme sports like BMX and surfing while Muse plays the song.

Touring members: Morgan Nicholls (2004, 2006–2022), Daniel Newell (2006–2008), Alessandro Cortini (2009), Dan Lancaster (2022–present)