[1] As a fight progresses, competitors faces can become swollen and bruised after being punched repeatedly, and blood from the fighters begins to coat the ground.

[2] Supremacy MMA is the second mixed martial arts video game to allow players to fight using female fighters, after the inclusion of Erica Montoya in 2004's UFC: Sudden Impact.

[1] The full roster includes the following fighters and their respective real world inspirations:[7] Supremacy MMA was announced on June 11, 2010, and the publishers stated it would be shown that year at E3 2010.

[2] While performing his review of the game, Greg Miller created a preview video showing the choppy animations, unresponsive controls, and echoing sound effects present during online matches, concluding the video stating, "I don't like this game very much.

"[12] GamePro appreciated the similarity between the fighters' depictions and their real life counterparts, but criticized the fighting system, musical soundtrack, and gratuitous violence particularly during the Mortal Kombat–style finishing moves, which often result in broken limbs or necks and do not follow the style of typical MMA fighting.