Ramachandran was committed to performing research throughout his career and much of it was done at a time when there was no formal funding or encouragement from the Ministry of Health, although his primary area of specialisation was nephrology his research reflected the General Medical Practice in rural Sri Lanka at the time and a strong commitment to General Internal Medicine throughout his distinguished career.

His research publications covered nephrology, malaria, typhoid,[3] diabetes, alcohol induced disease, Health care in the elderly, hepatic amoebiasis,[4][5] and leptospirosis.

[6] He worked at National Hospital Sri Lanka alongside colleagues such as Dr J.B. Peiris, Rezvi Sheriff US Jayawickrama and AH Sheriffdeen.

[9] He was the recipient of 14 gold medal orations [10] He was awarded the titles Deshamanya and Vidyaj Jothi for his work for the nation by the government of Sri Lanka.

He was President of the Ceylon College of Physicians 1990-1991 [11] and The Sri Lanka Medical Association in 1997 with his protege Devaka Fernando a full Professor of Medicine acting as his secretary.