She has appeared in a number of TV series as a guest star, as well as several recurring roles.

[1] Misner portrayed Grace Davidson on the ABC soap opera One Life to Live from March 12, 1999, to November 17, 1999.

[2] In 2002, Misner appeared in the film Chicago as Liz, performing the "Cell Block Tango" number.

In several episodes of the first season (2011) in Person of Interest, Misner played opposite Jim Caviezel as his ex-girlfriend Jessica in flashbacks.

She portrayed Alison Humphrey in several episodes of The CW series Gossip Girl and Sergeant Burnett in New Amsterdam (2008).