Her friendship with author Margaret Mitchell led to Myrick's role as a technical advisor and dialect coach during the production of Gone with the Wind (1939), ensuring the film accurately portrayed the accents, customs, and manners of the South.

Myrick also was a columnist, reporter, and associate editor for Macon-based newspaper The Telegraph, working at the paper for fifty years.

Myrick also taught at the Student Normal School of Physical Education in Battle Creek, Michigan from 1913 to 1914, where she also studied at the American Medical Missionary College.

The next year Myrick attended a physical education program at Harvard University during the summer before moving back to Georgia.

[1] While working at Lanier High School, Myrick started writing an advice column geared towards young girls and women called "Life in a Tangle" for Macon's Telegraph.

The articles were published under the pseudonym "Fannie Squeers" and quickly became popular, leading Myrick to quit teaching and begin working for the Telegraph full-time in 1928.

Following the film's release, Myrick gained prominence discussing her work across the country, earning her the title "the Emily Post of the South".

In 1950 she wrote a children's book titled Our Daily Bread about environmental conservationism that was used as an official textbook in Georgia, North Carolina, and Tennessee.

In 1956, the Progressive Farmer bestowed upon her their Woman of the Year in Service to Agriculture award, and the National Association of Soil and Water Conservation Districts recognized her work with a special citation in 1963.