Prior to this, she spent 14 years at the Pew Research Center studying the impact of Internet technology on healthcare, and was involved in the initial launching of U.S. News & World Report's website in 1995.

[3] Fox examined the social impact of technology on healthcare, including patients and caregivers who were crowdsourcing diagnoses and creating their own medical devices to solve their unique problems.

[4][5] After her time at Pew, Fox spent a year as an Entrepreneur-in-Residence at the Robert Wood Johnson Foundation.

[1][3] Fox was Chief Technology Officer of the Department of Health and Human Services[6] during the last portion of the Obama administration, from May 2015 to January 2017.

[7] Fox was not an engineer by trade, but drew on her anthropology background to connect healthcare professionals with structural solutions, calling herself an "Internet geologist".