She trained as an actress at the London Academy of Music and Dramatic Art, graduating in 1995.

[1] Wise is best known for her work in the soap opera EastEnders and the Channel 4 comedy Peep Show.

On stage, she has had roles in Christopher Shinn's Where Do We Live and in Nina Raine's Rabbit.

[2] She appeared in the final episode of Kavanagh QC, starring John Thaw, in 2001.

[3] In 2020 she appeared as Emily Helmsley in Father Brown episode 8.10 "The Tower of Lost Souls".