In 2001, Amy was cast as Chardonnay Lane-Pascoe in the ITV series Footballers' Wives, which made her a household name and earned her the New TV Talent Award by the Television and Radio Industries Club.
In 2004, Amy was chosen for the lead role of Valentine D'Artagnan in the Hallmark Channel film La Femme Musketeer, starring alongside Michael York, Gérard Depardieu and Nastassja Kinski.
In 2005, Amy appeared in films House of 9, starring Dennis Hopper, and Dead Fish, and worked on Bill Kenwright's stage production of Wait Until Dark.
Her most recent projects include films Lesbian Vampire Killers (2009), Psych 9 (2010), Pimp (2010) and Bonded by Blood (2010), and a stage production of Agatha Christie's Murder on the Nile (2012).
On 22 December 2010, Amy appeared in Celebrity Come Dine with me Christmas Special, competing against actor and musician Goldie, singer Tony Christie, and former Blue Peter presenter Janet Ellis for a prize of £1,000, which went to charity.